Cancer cure in microtubules

Continuing our research on the emerging science on the role microtubules play in cellular growth and disease.

Recent Approaches to the Identification of Novel Microtubule-Targeting Agents

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This paper is a comprehensive overview of emerging role of microtubules in treatment of various medical conditions.

The following excerpt is technically above my pay-grade, but it does confirm my initial "recognition" and "anticipation" of the importance microtubules will play in future medicinal science.

I am sure that "learned minds" will recognize the actual state of the scientific discoveries that microtubules are beginning to play in greater scheme of things. You be the judge.

some excerpts:

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https://www.frontiersin.org/files/A...-841777-HTML/image_m/fmolb-09-841777-g002.jpg

PROTACs
[quote[PROteolysis TArgeting Chimeras (PROTACs) is a technology that holds great promise for overcoming drug resistance problems as it allows the inactivation of the target protein by inducing its complete degradation rather than its sheer inhibition (Garber, 2021). [/quote]

..... more

....... more

And a scientific conclusion that I predicted several years ago.

Conclusion

https://www.frontiersin.org/articles/10.3389/fmolb.2022.841777/full#h5

And this is what I intended to share with interested readers and I have had some encouragement, but alas, my research has fallen on deaf ears from sceptical "learned minds" and years of research in this new area of scientific study are now in a closed thread and not open to further news from an exciting new area of medical inquiry. Too bad!

Below is the link to the entire paper and related science, including downloadable pdf
https://www.frontiersin.org/articles/10.3389/fmolb.2022.841777/full

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My gosh, those darn microtubes are the cat's meow aren't they?

 

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A veritable wompom of microbiology :


Of course, the role of microtubules in the process of cell division has never been contested by anyone on this forum. It is one of the things they are actually known to do.

 

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You can bet on it. Several years ago Penrose became intrigued by Hameroff's description of microtubule properties and behaviors and wondered if MTs could operate as nano-scale logic gates.

Here is a quote from another scientist;
Gordon Hogenson, M.S. Physical Chemistry, University of Washington, 6y

https://www.quora.com/What-do-quantum-physicists-say-about-the-microtubules-quantum-mind-theories

And here is the description of microtubule function from a dedicated scientist in this field, Professor Justin Riddle. PhD
https://www.youtube.com/c/JustinRiddle


Everything I have cited on the importance of microtubules in living things is actually gleaned from existing science and known to function as described by the quoted passages from those scientific papers. When you add all MT functions, it becomes clear that questions of cellular diseases (including brain cells) must involve the only connected organelle that meets all necessary electrochemical properties necessary to build a model. As I understand it the mitochondria is responsible for assembling and "knitting" the MT into nano scale amplifiers that allow for quantum processes to collapse in a controlled fashion. The mitotic spindle is one model of MT data processing at very fine scales.

Microtubules (and related filament) are real nano-scale data processors. How the neural network processes data can be measured. How it all works is what we are beginning to find out!

I am bemused by the lack of philosophical interest in the science of biological meta-physical consciousness, the evolving sensory excellence that has resulted in the ability to do the physical sciences to begin with.

 

Reported for thread hijacking.

 

Hijacking a thread I started?

Looks more like you are trolling my thread!

Please let me post what I feel is important and stop being the science police.
If you wish to post something important start your own thread and stop being a pain.

 

You are known for self-hijacking. Hijacking a thread is a pain in the arse whoever does it, as it wrecks any discussion.

 

I agree, and that post is perfectly suitable for the subject under discussion (see bolded).

Microtubules are critically involved in the mitotic duplication of cancerous cells.

https://www.khanacademy.org/science...cular-biology/stem-cells-and-cancer/v/cancer#

So why are you trying to destroy this thread?

 

Yes I have only posted claims that I could support with scientific excerpts from reliable sources..

I have contributed a library of serious literature on the state of neural and cytological science. and the dynamic information processes MT are involved in. Their utility seems to be practically limitless.

Cell biology

more......
https://en.wikipedia.org/wiki/Cell_biology

Would you agree that cancer is a disease of the cell? It would be logical to defend the disease at cellular level and especially during mitosis that is fundamentally performed by the mitotic spindle that copies the genetic codes for the new cell .

The link was to a reliable source engaged in cellular research. They'll find out the How. That is the hard work.
A lot of new information to process.

 

I go where the information leads me.

Cancer is the result of biological information. When this information damages or diseases the cell (cancerous), the only time to "fix" the cell's genetics is during mitosis, the production of new cells. The diseased cells cannot be repaired, they must be destroyed.

What you fail to see is that all those random links to peer-reviewed papers share a common denominator that does the actual data processing and transport, i.e. microtubules.

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https://commons.wikimedia.org/wiki/File:Signal_transduction_pathways.svg

Does this look like a computer? Note that all these arrows symbolize data transport via microtubules.

This leads to:
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

• Max Adrian, Martin Weber, Ming-Chi Tsai, Caspar Glock, Olga I. Kahn, Lilian Phu, Tommy K. Cheung, William J. Meilandt, Christopher M. Rose & Casper C. Hoogenraad.

Abstract

We do know that microtubules do the data transport.

Plants are also Eukaryotic organisms and cellular activity is regulated by microtubule data transport.

Plant perception (physiology)
This article is about the physiology of normal perception in multicellular plants.
(For pseudoscientific theories regarding paranormal emotion and perception in plants, see Plant perception (paranormal).)

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The leaf closing after touch in Mimosa pudica depends on electrical signals

https://en.wikipedia.org/wiki/Plant_perception_(physiology)

And all Eukaryotic organisms use microtubules for data processing and transport.

I don't do the science. I discuss it.

 

You complain that I do not specify what microtubules do, yet you also complain that I give you too much information about what microtubules do.
If you do not read what I post, you cannot know what information is contained in those pesky, but relevant cut-and-paste set of definitions in every post that show the incredible versatility of this tiny data processor and transport network.

Regulation of microtubule dynamics, mechanics and function through the growing tip

• Nikita B. Gudimchuk &
• J. Richard McIntosh

Abstract

https://www.nature.com/articles/s41580-021-00399-x

Oh, without microtubules there is no life or procreation

Microtubular Dysfunction and Male Infertility
Sezgin Gunes1,7 , Pallav Sengupta2,7 , Ralf Henkel3,7 , Aabed Alguraigari4,7 , Mariana Marques Sinigaglia5,7 , Malik Kayal6,7 , Ahmad Joumah6,7 , Ashok Agarwal7 1 Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey, 2 Department of Physiology, Faculty of Medicine, MAHSA University, Selangor, Malaysia, 3 Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa, 4 Batterjee Medical College, Jeddah, Saudi Arabia, 5 University of Sao Paulo, Sao Paulo, Brazil, 6 Alfaisal University Medical School, Riyadh, Saudi Arabia, 7 American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA

https://www.researchgate.net/publication/328450886

 

But I did not claim that information itself is causal. It is causal when the value of the information interacts with the value of other information.

Causation and Information: Where Is Biological Meaning to Be Found?

Abstract

https://link.springer.com/article/10.1007/s12304-020-09397-6#

That is what is being discovered today.

Reorganization of Microtubules during Mitosis

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Microtubules

During mitosis, microtubules transport genetic data to the daughter cell.

Interesting that microtubules are critical components for "data processing" and "consciousness".

I am posting the areas where microtubules are actively involved for data transport and data processing.
EVERYTHING that has to do with neural and/or cellular data transmission in ALL Eukaryotic organisms involves microtubules.
There is no "way too much", they do it all just right.

Unfortunately you do not read the supporting materials I include with all my posts.

And that simple statement shows your ignorance of the subject. So you think that all microtubules do is give structure to cells? Cytoskeleton is all there is?


You may want to look into the transport component of your neurons that make your cells and your brain act up.

In the brain alone, some 100 trillion neural synapses are connected ONLY via microtubules.
You may want to look at this discussion and what Penrose has observed what they do.

 

Ever wondered about the importance of microtubule polarity?

Microtubule polarity is instructive for many aspects of neuronal polarity
Abstract

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more........ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058238/#

Microtubule play a major part in just about every phase of cellular and neural dynamics
More pertinent info can be found here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880148/

 

Reorganization is data processing, no?
Simply put, every dynamic action or interaction is a process, no?

 

Check out the difference between laminar flow and turbulent flow, depending on the several properties of the system such as pipe diameter and water pressure.

The flow behaves in accordance with the mathematics (or if you want to call it the physics) of the entire process. There is computation going on. It's just not human computation.