View Full Version : Anti - Aging
Cris suggested a new thread on Anti-Aging. So here it is. Let us know the stuff that will keep you young and healthy for a long time. Because there are volumes of stuff and books out there, let us distill them to a few top ones. I will post my input later.
03-11-02, 06:00 PM
Yoga and Pilates!!! A must. Anyone who hasnt tried it, should. Also, I think keeping an open mind also helps. I ride around with my grandma and she will listen to my music and talk about things most grandmas wont talk about, and she still looks and acts really young. Also, she quit drinking and smoking along time ago. (Ultimate agers)
Do you mean Joseph Pilates?
I had never heard of Pilates before your reference. Looks like a set of physical exercises.
What is so special about Piates?
One claim I have seen many times for anti-aging is to follow calorie restricted diets.
Essentially you feel hungry all the time and only consume just above a bare minimum to survive.
On mice, experiments show significant increases in life-spans - around 40% I believe. They are simply fed highly nutricious food but very low in calories. The mice seem to be full of energy right into old age. They also seem to be more tolerant of infections.
However, I am really not eager to feel hungry all the time.
So far this seems to be the best natural method for anti-aging that I have seen.
This thread is probably in the wrong forum, I think biology might be a better location.
Do you agree?
03-11-02, 07:19 PM
Do you mean Joseph Pilates?
Yes, I do. Pilates is so "in" right now, everyones doing it. Theres videos, books, all sort of stuff. Anyhoo, I feel great while and after doing them. Also, have you seen what he looked like at 80? Alot better than most at 30. He combines yoga with strength training. Theres other stuff involved that I dont know about, so I cant talk to much on it.
This is as good a place as Biology, since we will talk about psychology, sociology, cognitive science, emotions and biochemistry in this topic. As in Yoga, meditation, stress management - nature vs nurture....
This may be the best useful topic in the entire forum. Some of the items one should check out is Arginine synthesis, www.lef.org, Dr. Andrew Weils website, Deepak Chopra, Glucose crosslinks, Metformin, HGH etc...
Keep them coming....
Ok let's see how it goes.
My past interests were with the Geron corporation and their finding on telomeres, that is where I think we are likely to see some real breakthroughs. But that is really in the area of genetics and biology.
When I first came across Geron it was being run by Dr Adam West, who has since moved on and is now one of the leading scientists in human stem cell research (private sector). he was at the center of the recent controversy when his group cloned the first human stem cells.
We have a lot to cover.
03-12-02, 03:27 AM
Anti-aging? Calories? Cloned human stem cells? What a crap!
I agree on Yoga. As well the exercises as the meditation technique. It keeps you young, body and mind. So nothing artificial necessarry.
Some people grow old because they worry too much and forget to live. It is the way you live your life and what you put into your body to keep it healthy and young.
Freedom is given to the young of mind! Not genetically engineered or cloned cells.
Well, have your fun with scientifical youth. I am out of this nonsense.
Nature people, nature! ;)
Oh Banshee, what are we going to do with you? You are so mixed up and confused.
Aging is a disease to be cured like any other. Try this link, but there are many. Science does view aging as a disease. http://www.drlam.com/WhatIsAging.cfm
You it appears like so many others have come to accept aging and the degenerative diseases that are associated with it as natural and acceptable. Well I have news for you, you’ve been brainwashed into thinking that because we haven’t had the means to fight it until now.
And for you to then call it crap when we try to discuss one of the, and probably the most important medical research in the history of mankind, is irresponsible, and shows significant ignorance on your part. Sorry for the lecture, but I do become very angry when people have such apathy towards wanting to fight against such unnecessary suffering.
Planetary Death Rate
(courtesy of the US Census Bureau)
1.8 humans per second
106 humans per minute
6,360 humans per hour
152,640 humans per day
55,713,600 humans per year
It's time we started fighting back.
I agree on Yoga. As well the exercises as the meditation technique. It keeps you young, body and mind. So nothing artificial necessarry. Nonsense, your life depends on so-called artificial aids. Ever taken a pain-killer, ever had an anesthetic, would you refuse a replacement heart if yours stopped, how about replacement limbs if yours were lost in an accident, etc, etc. Are you going to refuse all the help that science offers because of some foolish new-age notion that only nature is necessary?
Some people grow old because they worry too much and forget to live. It is the way you live your life and what you put into your body to keep it healthy and young. True, and many others have genetic disorders that massively shorten their lives unfairly. Shouldn’t they have the same chance as everyone else?
Freedom is given to the young of mind! Not genetically engineered or cloned cells. Sorry but that is BS.
Nature people, nature! That is more BS. There is nothing special about nature. It is largely a random and chaotic mechanism. It causes cellular degradation and eventually causes death. Nature is something to fight against and not to encourage.
Life is the most precious thing we have. I intend to fight to keep mine whatever the cost, because if I lose it then I will cease to exist and that is just not acceptable.
Laugh if you like, and then die like the rest. But if you give any value to life then you too should want to know how to increase it, make it more endurable, and increase its quality.
03-13-02, 10:00 AM
*Aging is a disease to be cured like any other. Science does view aging as a disease.*
Now that is BS! Aging comes with life! Science is made up by humans. They better spend their time by helping the humans who die of starvation!
*And for you to then call it crap when we try to discuss one of the, and probably the most important medical research in the history of mankind, is irresponsible, and shows significant ignorance on your part. Sorry for the lecture, but I do become very angry when people have such apathy towards wanting to fight against such unnecessary suffering.*
I don't have apathy towards fighting against unecessarry suffering! You don't know me very well Cris, so who are you to judge me???!!!
The most important medical research in history. :confused: Yeah, right! Forget it! BS! Ignorance on my part? Think again please! What about all the humans who die because they don't have access to these scientific inventions? I stay with my statement. Aging is a natural process of life. What do you think? Everybody lives on forever? You want to play the part of the creating forces which are responsible for us, which gave us life.
*Ever taken a pain-killer, ever had an anesthetic, would you refuse a replacement heart if yours stopped, how about replacement limbs if yours were lost in an accident, etc, etc. Are you going to refuse all the help that science offers because of some foolish new-age notion that only nature is necessary?*
Yes! I've had anesthetic and I am dependable on pain killers. I hate it! Yes, I would refuse a replacement of my heart, if mine is not good any more. Without hesitation too! Don't you know the heart is personel, you change, carrying the heart of someone else. Never heard about that? An artificial heart is totally out of the question, I am not a robot, or an artificial half-human. No! I don't want artificial limbs, for the same reason.
I am not a fool and not new-age thinking!! I have always been this way. From child on!! I sam sorry to disappoint you.
*...and many others have genetic disorders that massively shorten their lives unfairly. Shouldn’t they have the same chance as everyone else?*
How you think these genetic disorders exist and even increase now-a-days?? I'll let you figure that one out for yourself! Damn, what the hell do you think?
*There is nothing special about nature. It is largely a random and chaotic mechanism. It causes cellular degradation and eventually causes death. Nature is something to fight against and not to encourage.*
Nothing special about Nature??? Now I am starting to think you are a fool! Nature is something to fight against? Oh Cris, you're as lost as all the others. Where is your Inner Sense, your Intuition, given to you by Nature. Don't you see? The human race is fighting itself and you don't even realise it. Tragic...:confused:
*Life is the most precious thing we have. I intend to fight to keep mine whatever the cost, because if I lose it then I will cease to exist and that is just not acceptable.*
You don't lose life! Your Earth-bound body dies, not you. You will come back to live another life-time. Cease to exist? You are confused here, you lost contact with Nature and the Cosmos. Not acceptable? It is part of life that your body dies. It is not a big thing you know, it is Nature, Cosmos, Life!
*Laugh if you like, and then die like the rest. But if you give any value to life then you too should want to know how to increase it, make it more endurable, and increase its quality.*
Laugh??!! Nothing to laugh about this here! I do give value to life, by living it the best way I can. Trying to understand others and help them if necessarry. Be true to Nature at all costs. And to life. I increase its quality by giving value to other humans and their needs and loneliness. Don't need material well being, do need life and love. Fight my way through darker days and help the ones who need it. I give love and live my life as valueable as possible. When I die, it is because it is my time. I will be back, as always...
Never the less, I do like you Cris. You are a clever person and I do have much respect for you. Hope we don't going to argue about this. I just live my life in another way, it has never failt me, my way of living. I have gained a lot. No New-Age, please, understand that well. I have nothing to do with New-Age!
Let us stick to the science, technology and medicine please...
I have been to nursing homes. We have two of them near by. It really saddens me to see those people suffer. The doctors call them age related disease. The major portion of your life, you contribute to your society, family and friends, and then old age hits you and you are in a nursing home waiting to die while suffering to the max. That is natural? How many animals you see in nature that move to old folks (animals) shelter and wait years to die?
Banshee, I recommend you visit a few nursing homes and report to us, what you see. Then you will understand where we are going with this thread. Thanks.
Never the less, I do like you Cris. You are a clever person and I do have much respect for you. Hope we don't going to argue about this. I just live my life in another way, it has never failt me, my way of living. I have gained a lot. No New-Age, please, understand that well. I have nothing to do with New-Age!Banshee, actually I do have a lot of respect for you as well, based on many of your other posts. But we do have some major philosophical differences, and I was aware of that. Knowing that, I was being deliberately confrontational with my post.
Nature is both our ally and our enemy. If we do nothing it will kill us, if we work with it and understand it, it can help us.
But death due to aging is not a natural process. Aging is the result of the breakdown of natural processes. And not all life-forms age. Bacteria for example has no aging process. Theoretically the very earliest bacteria from millions of years ago could still be alive if they have managed to find food. Some cacti also do not age, as do some trees.
But our main difference is a philosophical belief in an afterlife. You believe you will survive death through a supernatural process and I don’t believe any such thing.
But really our long-term outlook is identical. We both want to live forever. You hope you will achieve it that through an afterlife and I expect to achieve it through science. Our philosophical views have determined how we approach how we live and our eventual future.
However, if you are wrong, then you will cease to exist when you die. If I am wrong, then I will live in an afterlife. But if I am right and there is no afterlife then I fully expect science to solve the problem in my lifetime, and if not then I am scheduled for cryogenic suspension. Either way I believe I stand a good chance of survival whatever happens. You on the other hand are pinning all your hopes on a supernatural realm that no one has yet show can or does exist.
I believe your attitudes, which I think are unfortunately typical of many, represent a lazy and fatalistic outlook, a feeling of helplessness that it is not possible to avoid death. I think that view is tragic. I have been watching anti-aging research for the past 20 years and there are some remarkable breakthroughs occurring right now. It seems it is inevitable that human life-spans will be increased significantly to ages of 300 plus and the treatments should be available within the next 15 years. Beyond that it seems most likely that such treatments will be further refined resulting in life-spans that are open-ended.
I will post the links and discuss such research in this and other related threads.
Sorry about the new-age reference, I was somewhat winding you up.
I lost my sister to cancer when she was 55 and I lost my brother to polio when he was 7, and my father to aging with years of suffering when he was 92. Death is the next frontier of the human race, and it is within our grasp to solve very shortly.
I feel truly sorry for you if you are content to accept death. I see no reason to believe there is anything such as an afterlife and I do see much that suggests that no such thing exists. I’m simply not prepared to sit around and wait to find out.
Let us stick to the science, technology and medicine please... Yes OK, although the acceptance of anti-aging research and the philosophical issues that will result if science does solve these issues, will have important repercussions. Both the science and the philosophy will need to go hand-in-hand on this.
Issues of population growth, for example, will have dramatic effects on the economic and political outlooks for the whole planet. This is a case where scienctists must be aware of the implications of their reseach.
However, in the meantime let's concentrate on what is actually possible, and the short term outlook.
OK, first the disclaimer: anything I express here should imply that it is my opinion based on my own observation in human science and my own research. So, any statement I make should not be confused with the absolute truth and hence please no debate over it. The words implied here are 'should be', 'may be','could be' IMHO, and such....
Health Science is a hobby of mine. Many years ago, I was admitted to do a MD/PhD program. My interest was to do research in neuroscience. Lack of money prevented me from my objective. Anyway, I have done extensive research in Ayurvedic, homeopathic, and standard western medicine etc.
Now, I think, Cancer is the result of our environment, both internal and external. A good friend of ours died from liver cancer at age of 38. She was perfectly healthy mormon, no drinking, no smoking, easy going person. The only differential between her lifestyle and ours was: She handled herbicide and pesticide on a regular basis since she loved gardening. She also did a lot of ceramic art and loved to eat rare meat and acidic foods.
Based on my conversations with a premier breast cancer specialist at University of Utah medical Center, I learned that most cancers have a very strong co-relation with prolonged stress in one's life. And that, 85% of the disease is caused by long term stress.
03-13-02, 03:10 PM
For your information, I have been working in a nursing home. I know very well what happens to humans who are suffering from an aging disease. There are treatments for that and they get better and better. Who do you think I am? Some idiot who knows nothing from life and how humans live...:confused:
Further more, I don't believe in an after life, I know there will be a new life, here on Earth. Another life-time. There were life-times before this one.
Why do you want to stick to the science, technology and medicine? In other words, I cannot post here? Why not?? Because I think it is ridiculous scientists invent an anti-aging pill in stead of inventing a program to save humans from starvation?
Ah, well, I see how you do that. Poor humans who suffer from an aging disease, no poor humans who die of starvation... :rolleyes:
There are treatments for that and they get better and better. If that were true, wouldn’t they then live forever?
Further more, I don't believe in an after life, I know there will be a new life, here on Earth. Another life-time. There were life-times before this one. But you do believe in some form of essence that represents your soul or spirit, or something that represents an eternal you. Is that correct? Whatever terminology we choose you believe that the death of the body does not mean that ‘you’ die, is that fair?
Why do you want to stick to the science, technology and medicine? Because this is a science forum.
In other words, I cannot post here? Why not?? I’d like you to post here, but with the constraint and acceptance that the object is to primarily discuss science, regardless of whether the particular science should be done or not.
Because I think it is ridiculous scientists invent an anti-aging pill in stead of inventing a program to save humans from starvation? Why? Very few people die from starvation compared to those who die from aging related diseases. I think your priorities are mixed up.
If you work in a nursing home, you should be the perfect person to discuss life and what is being done to alleviate their sufferings. We could learn from that a lot - instead of getting your thong up a knot.
Get with the program, lady...
I would say that if you want to live forever you should come up with an invention that keeps the cromosoms from becoming smaller for each time the cell duplicates themselves... like it works on a cancer sell... but I do not think that It would be a good idea to have eternal life because it would stop the idea of natural selection... and evolution would stop... :)
Sorry for my bad english... :)
You are talking about telomeres and there are chemicals that inhibit and there are that let it get shorter as in cancer patients...thanks.
03-13-02, 06:45 PM
* Very few people die from starvation compared to those who die from aging related diseases. I think your priorities are mixed up.*
No, my priorities are not mixed up, a lot of humans are dying from starvation. Never heard of Africa??
Further, I have been working in a nursing home, as a volunteer. Don't work there any more. Perhaps the good word should have been worked. My English is sometimes not entirely good, my apologies.
And yes, I know there is a Earth-bound body and a Cosmic body. Call it belief if you want to. I don't like the word 'belief', too much of a religion.
I'll go with the program. Talk to you later, I really have a bad day today...
No, my priorities are not mixed up, a lot of humans are dying from starvation. Never heard of Africa?? You missed my point. I don’t disagree that many people die of starvation, but the number is insignificant when compared with the number of people who die due to aging related disease.
But starvation is not an issue for science; that is both an economic and political issue. There is plenty of wealth and food around to prevent anyone starving, or at least the means to produce adequate food, so I suggest you take that up in the politics forum.
And yes, I know there is a Earth-bound body and a Cosmic body. Call it belief if you want to. I don't like the word 'belief', too much of a religion. To know means to have knowledge and knowledge usually comes by way of evidence – uhh whatever, wrong forum for that. The point is made that you think you have an essence that survives bodily death. It is that perspective that seems to have persuaded you to have an opposition to anti-aging research, would you agree?
But there are more urgent needs to solve the problem of aging rather than just allowing people to live forever. And again this is both social and economic, but has a scientific solution.
In many parts of the world, the wealthiest for the moment, although it looks like the rest of the world will follow shortly, the proportion of elderly people is increasing compared to young people. This is creating a problem that will become a major issue in a few years time. It is the younger people who create the wealth, i.e. they are the workers who produce the goods, which are sold, etc, and which generate an active economy. If the number of workers decrease and the number of elderly increase, then where is the wealth going to come from to support the elderly?
Many elderly may have provided good pensions for themselves, but most do not do that. But the real issue is that as people age they succumb to age related diseases. IOW words as you age your body’s ability to fight off infections decreases rapidly. This puts an increasing burden on the medical services that have to be funded somehow.
The USA and most countries in Europe that have active welfare schemes know they are facing a crisis in a few years time.
Up until the mid forties the concept of retirement didn’t really exist. People would work until they died. But modern medicine had made it possible for people to live longer and the average lifespan was creeping into the 50s and 60s. People were living longer and some were saving enough so that they could stop work and live a life of leisure. Most western countries then adopted the concept of retirement and the idea of pensions, mostly state funded.
This seemed like a good idea and was politically popular. But what age to set for retirement? At that time the average life-span was 63, so a retirement age of 65 was set. The expectation was that not many would live past 63 so pension schemes could be very easily financed.
Unfortunately science has continued to help people live longer. The average now for males is around 73 and 79 for females. But it isn’t just a few exceptions but the bulk of people.
The crisis will come in the provision of medical services and the means to finance that.
One obvious solution might be to make people work longer, perhaps set a retirement expectation at 75 instead of 65, and there are trends that indicate that is starting to happen. But while people are living longer they are also experiencing many more age related diseases that will prevent many of them from working. And unfortunately science is finding ways for people to live longer but not particularly with a good quality of life.
The solution to both the economic and the quality of life issue is to find ways to prevent the aging process. If people stay effectively young, then they can work longer if they wish, the drain on the medical services will dramatically subside, and the overall quality of life will dramatically improve.
The next problem will be overpopulation and how to control that. And that I hope will provoke more research into space exploration. There is a massive universe out there and we have not begun to explore it yet. It is time.
So anti-aging research is vital for economic, and political stability, as well for the quality of life for all humans. I heard a few years ago that the US government spends more on anti-aging research than they do on defense.
03-13-02, 09:03 PM
To stay young I recommend:
No smoking of tobacco
No drinking of alcohol
No frowning :mad:
Drink lots of water
Good skin care
Dress in many colours
Lots of playing
Laugh as ofthen as you can
Soft lighting next to mirrors
Have a vivid imagination
..it helps for me anyway, without any scientific investigations or evidence whatsoever. :D
Oh, and I almost forgot..always be in love. :p
Just a few notes -
Dress in many colors – does jeans and casual shirts (different color every day) count? I never wear suits and ties.
Soft lighting next to mirrors – don’t have any mirrors, apart from one in each bathroom. But all my lighting is indirect and soft, even in my office.
Ignore time – I let Outlook tell me where and when I should be, and I usually don’t wear a watch.
without any scientific investigations or evidence whatsoever. Good choices and there is tons of evidence to support you.
Oh, and I almost forgot..always be in love. Does loving myself count? I have a committed single lifestyle. I.e. I don’t date anymore, much too stressful.
03-14-02, 10:26 AM
How do you think it comes, that there are more elderly people then young ones? Because everybody is kept alive longer. Artificial or not.
Besides, my grandmother died on the age of 98 years old and she didn't have an aging disease. She was the happiest and brightest woman I know...
*To know means to have knowledge and knowledge usually comes by way of evidence – uhh whatever, wrong forum for that. The point is made that you think you have an essence that survives bodily death. It is that perspective that seems to have persuaded you to have an opposition to anti-aging research, would you agree?*
No, it is the point that people are kept alive longer and longer. Its against all odds.
Well, if the worlds society from now-a-days askes for anti-aging medicine, then let it be so. More elderly people and lets see where it goes.
Time is not in my life either. Never had a watch, only during my schooldays, hanging at my book-bag, to see if the class-hour was nearly over. Ever since, I never had a watch. I don't live in time, it is only necessarry if you have an appointment. A necessarry 'evil'...
03-14-02, 12:40 PM
Laugh as ofthen as you can
Uh oh, wrinkles:D
But OK if we do all those things how much time will that buy us, a few years, a decade or two? Really not very much. Once the build up of oxidation takes over and telomeres wear out, you’re dead.
At best it is reckoned that about 120 years, with good quality, is what we can expect from optimum lifestyles and appropriate diets and supplementation. After that we need to solve the real problems that cause cellular defenses to fail and chromosomes to decay.
We are gradually beginning to understand the mechanisms of aging, although there is still much to be done. It is fully expected by many scientists working in the field that it is only a matter of a short time before we do have effective medical treatments for slowing, stopping, and eventually reversing the aging process.
The result of course will be that people will simply not age. The only way to die will be by accident, murder, suicide, or a fatal disease for which we have not found a cure.
From a personal philosophical view I expect that once we achieve the status of having potentially eternal life-spans that life will be viewed as immeasurably more valuable, priceless in fact, and that all means would be taken to protect it. Wars will become unacceptable by orders of magnitude compared to our current views. And religious beliefs will have to be re-examined to assess whether there is any meaning left to them.
So next post - ‘telomeres’.
A good article from Scientific American, although there are many others our there –
Some short extracts -
It may not sound as appetizing as aquavit, but telomerase--an enzyme discovered only a decade ago in a single-celled protozoan--may well be the elixir of youth. This chemical acts in immortal cancer cells, sperm and ovum to repair telomeres, the strands of DNA that tie up the ends of chromosomes. And now it seems that activating telomerase in sundry other cells grants them a longer lease on life as well.
But does lengthening the telomeres actually prolong the life of human cells? Groups from Southwestern Medical Center and Geron proved just that in the recent Science article. By introducing the hTRT gene, they caused three different kinds of cells--retinal pigment epithelial cells, foreskin fibroblasts and vascular endothelial cells--to resume telomerase activity.
In all three cell lines, the telomerase knit new DNA onto the ends of chromosomes, artificially elongating the telomeres. And all three lines lived much longer than usual. Whereas unaltered cells in the study reached senescence after a fixed number of divisions, the hTRT-positive cultures had seen 20 population doublings beyond that point at the time the report was published--and they were still going strong. "We have found that cellular aging can be bypassed," said Jerry Shay, who headed the Southwestern Medical Center team with Woodring Wright.
03-15-02, 07:38 AM
I humbly bow my head and leave the thread quitely...;)
Just got an email to buy aeon which allegedly contains Somatotropin. I did not think you can buy HGH without prescription. And even then, there is any spray delivery or patch system that I can find.
I humbly bow my head and leave the thread quitely...
I think you promised something similar earlier in the thread, but you came back.
So I suspect you'll be back. You are simply much too curious. And really deep down you know I'm right in everthing I say, right? And you long for my next revelations of wisdom, right?
It looks like just you and me on this topic. Rest are too young to care...
are you serious?:confused:you are a Sanatan Dharma practising person right?i woudnt accept that from you at least...are you afraid of dying?i am sure you are not.(very positive about this!)...:confused:
Out of all the people, you should know that yoga and meditation is part of Sanatana Dharma (SD). Why? to keep body and mind healthy untill your time to meet the maker. The entire Ayurvedic medicine has tons of stuff that reduces age related illness or problems.
Tradition says that yogis lived twice the age of normal people. So where is the conflict? Why suffer because of stupidity? I also practice Gyana Yoga (Yoga of Knowledge). What is knowlege? It is the ability to utilize the data for the benefit of the body, mind and spirit....you get the idea....
Got your point.
03-19-02, 06:01 PM
Well, it would definitely be interesting to see what happened with humanity if we could become physically immortal. So keep working on it, you scientists. :)
But right now, it feels like an unnecessary luxury when there is so much else to straighten out, people are starving to death and killing eachother mostly beacuse of greed, is there no cure for that instead?
03-19-02, 08:22 PM
Cris*And really deep down you know I'm right in everthing I say, right? And you long for my next revelations of wisdom, right?*
Originally posted by Bebelina
*But right now, it feels like an unnecessary luxury when there is so much else to straighten out, people are starving to death and killing eachother mostly beacuse of greed, is there no cure for that instead?*
Now I am curious for your answer on this...:)
How is starvation and greed connected to anti-aging research?
I agree that starvation and greed are not admirable aspects of life, but what is your point in bringing up the subject here?
03-20-02, 12:21 AM
Why should research into anti-aging be sacrificed because part of the world has not solved the problem of feeding/supporting its citizens? Or for that matter, when has the greed of some members of mankind been an adequate reason to abandon or ignore man’s (other) potentials to improve--or prolong--his existence? Those who are not interested in anti-aging are free to age as naturally as they like. No one is forcing them to live longer.
Because some people feel a concern, or even a responsibility, for the general welfare of others, does that mean that all of mankind should share the same level of concern? The reality is that we don’t all share the same levels of concern or interest, and we’re never going to. Anti-aging research is not standing in the way of people being fed, and has nothing to do with people being murdered.
Who has the right to tell me how to spend my own money? Who has the right to tell me what should be important to me?
The topic is anti-aging. It would be nice if some real discussion were allowed to happen.
I thought Telomerase are responsible for Telomere formation and constrictions caused in mitosis,:confused:
Resveratrol's anticancer mechanism defined
Researchers at De Montfort University in Leicester, England, have discovered the mechanism of action of resveratrol against cancer. Resveratrol, a substance found in grapes, had been previously demonstrated to have cancer-fighting properties, but how it is able to do so has heretofore been unknown. The researchers discovered that resveratrol is converted in the body by the cytochrome P450 enzyme CYP1B1, found on a variety of tumors, to a substance called piceatannol, a tyrosine kinase inhibitor which is toxic to cancer cells. The process is restricted to the tumor, preventing toxicity to healthy cells.
Resveratrol is naturally produced in plants such as peanuts and grapes to aid them in combating fungus. It was previously believed that the enzyme CYP1B1 was involved in initiating cancer, because it is found only in tumors. The study provides additional insight into CYP1B1's role as a growth suppressor enzyme.
03-24-02, 01:59 AM
Cancer adjuvant treatment
Many types of cancer cells use an enzyme called cyclooxygenase-2 (COX-2) to propagate. This includes cancers of the colon, pancreas, breast, prostate, bladder, lung, head and neck, to name a few. The good news is that COX-2 is also involved in the rheumatoid arthritis process, so there are drugs that are already approved to treat arthritis that may also be prescribed for cancer patients.
Drugs that inhibit the cyclooxygenase enzyme are known as COX-2 inhibitors. The two newest COX-2 inhibitors are Celebrex and Vioxx, but we suggest that cancer patients consider older drugs that have a more predictable safety history. One drug that oncologists may consider prescribing is Lodine XL, a drug used to treat arthritis that also interferes with COX-2 activity. A safer COX-2 inhibiting drug called nimesulide is sold in Europe but is not yet approved by the FDA.
Scientists are now actively investigating COX-2 inhibitors as drugs that would be effective in both the prevention and treatment of many cancers. When COX-2 drugs are given to patients with colon polyps (precancerous lesions), the lesions completely disappear. When a group of rats were given a potent carcinogen, there was a 90% reduction in those who developed cancer if they were on COX-2 inhibition therapy. In the few rats that did develop the tumors while taking COX-2 inhibition therapy, the tumors were 80% smaller and less numerous than in the group not on COX-2 inhibition (Wall Street Journal, Sept. 7, 1999).
We predict that COX-2 inhibiting drugs will eventually be approved to treat cancer, but in the meantime, cancer patients should ask their doctors to consider prescribing a COX-2 inhibiting drug as an adjuvant therapy.
Until someone comes up with one pill that covers everything, you have to take a whole lot of pills to cover everything from heart disease to prostate to cholesterol.
I wonder if hGH will solve these problems...if anyone on this forum is a biochemist, get going on this stuff now - one pill or patch.
03-24-02, 11:22 AM
What I find most encouraging about this news is that drugs like Vioxx and Celebrex have already become popular, with patients and physicians. We could say they are fairly well established in the market. Also, insurance companies are now paying prescription claims for Celebrex more than they have in the past, (though many still prefer a patient try Vioxx first and do their best to avoid paying more than they have to.)
I've often wondered about how many "drugs" we have that are already available, but which might have hidden assests. And of course the only way to discover such hidden treasures is to do research. Lots of it.
What a boon for mankind... to discover truly effective ways to combat or to eradicate a killer like cancer.
Yes, we have several medications that have beneficial effects that are already on the market and more are on the way. 10 or 15 years ago, we did not know and a lot of people died unnecessarily.
The following medicines (that I can remember) have mulriple benefits.
Celebrex: Cancer, Arthritis
Metformin: Diabetes, Glucose cross-linkage, fat burning, PCOS
ACE inhibitors: keeping arteries clean
Medicines needed but available in herbal form:
Advanced Glycosylation End-products Cross Linkage Breakers (Age Spots)
A review article coauthored by researcher Bruce Ames PhD of the University of California, Berkeley, published in the April 2002 issue of The American Journal of Clinical Nutrition featured the assertion that over fifty genetic diseases are successfully treated with high doses of vitamins, particularly those of the B complex, and that the vitamins may slow the effects of aging. Dr Ames suggests that there may be many more diseases treatable with megadoses of vitamins, and that the similar biochemical deficiencies of aging may be responsive to megavitamin therapies as well. Young people as well, may find vitamin supplementation useful to tune up their metabolism.
Dr Ames believes that the effectiveness of megavitamins are due to their role as coenzymes, which work with enzymes to perform metabolic functions. Certain genetic mutations reduce the ability of an enzyme to bind to its coenzyme, therefore decreasing the rate of the enzyme to catalyze a reaction. High levels of the right vitamins will raise the amount of coenzymes to a level sufficient to overcome the defect, reversing the effect of the mutations. Dr Ames and his coauthors have estimated that up to one-third of all genetic mutations result in the corresponding enzyme having a decreased binding affinity for a coenzyme. Examples of diseases that can in some instances be caused by mutations and which are responsive to high doses of vitamins cardiovascular disease, migraine, some cancers, alcohol intolerance, blindness, kidney disease, mental retardation, hemolytic anemia and Alzheimer's disease.
Dr Ames commented, "These 50 diseases are just the tip of the iceberg. Individual doctors have noticed this, but nobody put it all together. Now, doctors are going to try high-dose vitamin therapy the minute they know a coenzyme is involved in a disease or there is a problem with the substrate. It makes sense, since many of the vitamins are generally recognized as safe in large doses. I think this kind of thing will turn up all over once people start looking."
Dr Ames notes that B vitamins are sold in dosages hundred times the recommended daily allowances and are considered safe for most people. The review's authors write, "There is potentially much benefit and possibly little harm in trying high-dose nutrient therapy because of the nominal cost, ease of application and low level of risk."
04-06-02, 01:49 PM
I think we have every right to expect that our science will change the nature of aging. It has in fact done this in the last few decades. One of my long time friends has been on hGh longer than anyone as far as I know.
Lazarus has been on hGh since he was 59. At that time he looked and felt very old compared to how he looks and feels now. He is now 70 and believes he would not have made it this far if he had not started on hGh when he did.
You can read his story on his web site
The Rejuvenation and Longevity Foundation (http://www.anti-aging.org)
I am only 38 and I am not aging all that fast since I exercise eat pretty well and take some supplements as well. I also stay out of the sun unless it is necessary.
We have been looking into natural bacteria that can have the genes infused into them that make hGh and implant them into the small intestine. This would bring down the cost of treatment.
Another possible help is to use an enzyme treatment that stimulated regrowth of the pituitary gland itself. This would eliminate the need to administer added doses of the hormone when the body simply does not produce enough to support our continued life.
We have been looking into natural bacteria that can have the genes infused into them that make hGh and implant them into the small intestine. This would bring down the cost of treatment.
Very good idea. Yogurt for the old folks. I would like to see more fortified banas, apples etc that produce DHA, Vitamin A and E in large quantities.
We definitely need a hGH patch to absorb through skin now, while working on the Yogurt method. People are peddling hGH in homeopathic formula - I think that has no effect on human body - except on your wallet. The Homeopathic idea is that if you take in picogram quantities for items that your body lacks, your body supposed to get a signal to produce more. I am not sure that is a good theory that has been tested.
04-06-02, 08:21 PM
It is my experience in experimenting with this that by itself the Homeopathic method for increased hGh production is not effective at all. With the added precursors it can be effective to a point.
All that is not effective if your pituitary gland has shriveled up to the point where it is not producing much of anything. All the precursors and Homeopathic hGh will not do you a bit of good.
The enzyme treatment to stimulate the rebuilding of the pituitary function holds promise IMHO at making some difference.
I look at people like Lazarus who would be dead if not for injected hGh and I know when it comes to the point where I am their age I want to have better technology worked out.
The patch is not a bad idea but the solvents that bring the aminos below the skin might tend to break the elements down.
a subdermal micro-implant using the bacteria but in a regulated output environment is likely going to be an effective treatment.
04-06-02, 08:24 PM
While HGH is interesting some caution is in order. Mice modified to produce extra GH became HOOGE and died young. Mice with the GH gene “knocked out” became dwarfs that outlived the normal species. There is reason to believe HGH increases cell division and that might increase the chance of cancer.
In this hamster’s opinion HGH would likely shorten life span when given to young people and lengthen life span when given to elderly. HGH might improve the quality of life for middle-aged people while shortening their life span.