It appears that mitochondria...the once bacteria and now an essential powerhouse of the cell refuse to go into Apoptosis and activate an efficient energy saving mechanism of NAD+ production when cells are not over nourished. And this is the reason why people who eat a bit of food live longer. A more concise explanation of this phenomenon can be found here: http://www.medicalnewstoday.com/articles/83268.php Quoting: So we can make a molecule that activates these genes responsible for mitochondria efficient energy cycle...and thus prolongue cell life. Please Register or Log in to view the hidden image!
I wouldnt mess with apoptosis, mostly when mitochondria is damaged/not working, cells cant go into apoptosis and with few other mutations you have a cancer cell.