organ replacement

Discussion in 'Biology & Genetics' started by Avatar, Sep 2, 2004.

  1. Avatar smoking revolver Valued Senior Member

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    An idea came to me when I was thinking about how animal hearts are operational proportional to their beating rhytm. the faster the pulse the shroter the years a heart can operate. mouse vs an elephant.
    so would the problem be solved if when reaching certain age the heart is replaced with an organic transplant or better yet -> an artificial heart.
    The next step would be lungs, kidney.. etc.
    When an animal ages his immune system gets weaker, so presumed the animal is a human, why not feed him the medicine AIDS patients get for treatement?
    as you have probably gotten it by now I'm thinking of prolonging the human life.
    If we replace all worn out organs and keep the immune system up...
    what do you think of that?

    Of course there still remains the problem of cells not dividing any more, but that is gene therapy already and I'm not so good at it at higher levels than new scientist and school book articles

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  3. spuriousmonkey Banned Banned

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    If you do a heart transplant you would need immunosupressing drugs.
     
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  5. Avatar smoking revolver Valued Senior Member

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    hmmm, you're right... letseee
    grow replacement organs using the subjects own dna as base material
    or fooling the immune system to think that the new organ is its
    I'm in a great hurry atm.. will think of smthing more plausable then after
     
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  7. spuriousmonkey Banned Banned

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    you do that.

    May I add that it is not really feasible yet (or in the near future) to grow something as complicated as a human heart.
     
  8. John Connellan Valued Senior Member

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    The brain will then become the limiting factor
     
  9. ElectricFetus Sanity going, going, gone Valued Senior Member

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    xenotransplantation using engineered animals can result in animals that can provide spare organs with little risk of rejection, but it will be some time until such a universal donor is engineered, even so biotech has been working on animals that are more compatible immunologically with humans, once it’s possible to produce animal organs with the rate of rejection equal to human organs we will start seeing organ “farms” sprouting up at a hospital near you.

    Also engineered immune suppressed animals can be used as host to grow human organs.
     
    Last edited: Sep 5, 2004
  10. sargentlard Save the whales motherfucker Valued Senior Member

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    What sort of animals are we talking about here?

    Pigs? Horses? Something big?
     
  11. ElectricFetus Sanity going, going, gone Valued Senior Member

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    from what I have seen I'm guessing pigs, goats, cows and rats heck we already have rats growing transplantable skin and catalige. I have read an article in SA about using pigs to grow penises on their back... I guess there is a market for that.
     
    Last edited: Sep 5, 2004
  12. hotsexyangelprincess WMD Registered Senior Member

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    whoa. why would you want to do that? :m:
     
  13. spuriousmonkey Banned Banned

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    There is lots of money in impotency.
     
  14. sargentlard Save the whales motherfucker Valued Senior Member

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    Large penises are a thing to be proud of in Western society and Viagra is the fastest selling drug in history.

    Also for the rare instances where a penis is cut off, burned, damaged etc etc.
     
  15. Avatar smoking revolver Valued Senior Member

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    or somebody wants 2 of them

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    g2g

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    I'm on tight schedule
     
  16. Shoshi Registered Member

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    I am not even going to adress the pig remark as I have heard nothing of it. I do know that a human ear has been grown on a knockout mouse/rat. A knockout animal is one in which either selective genes are altered or knocked out completely. These mice and rats are normally used to test medicines and the like because we can give them a human immune system in place of their own using the knockout technology. If the technology has graduated to larger anmals, then I would guess you could grow organs that way. I would thing, though, that to prevent rejection (since they usually still have to have some sort of immune system to survive to donate the organ) one would need to splice in the person's DNA and wait for the organ to grow.

    Might be nice for those pretty far down on the UNOS list due to non-severity of disease at this point. Those higher up on the UNOS list probably wouldn't have time.

    I have seen the knockout mice, though, and they have a high failure rate. Just surviving to adulthood is a feet for some strains of them. I would think the failure rate would only go up as we tinkered more and with more complex animals.
     
  17. invert_nexus Ze do caixao Valued Senior Member

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    What about headless clones? It seems that we don't have the means to provide the proper framework for complex organs. But, if we used headless clones (or maybe even brainless clones) then the body would provide the structure.

    I suppose the problem with this would be that one would have to wait until the body was mature in order to harvest the organs. And in the case of the heart you might get a younger heart and healthier heart but you'd never get a fresh never before been used heart.

    The question is, which organs require full maturity before they can be transplanted? Which organs can be used from a child clone? What would be the minimum time span alloted to growing the clone? Might there be a way to speed the growth of the clone without causing undue stress and damage to the required organs?
     
  18. Shoshi Registered Member

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    Speeding growth has been shown in animals to cause some serious side effects, including death of the birth mother over time because the animals are getting larger and larger at birth.

    As for what organs must be at full maturity....most organs are at full maturity when a child is born...just WAAAAY to small for a human adult. Children might benefit from this except, as far as I know, we have yet to find a way to clone a human and most especially a headless or brainless one since the heart and organs need the brain to tell them what to do.
     

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