Antibody Cocktail?

Discussion in 'Biology & Genetics' started by KUMAR5, May 29, 2021.

  1. KUMAR5 Registered Senior Member

    Messages:
    923
    Hello.
    Greetings!

    A new therspy to treat Covid-19 is recently introduced in INDIA. It suggests:-
    "Cipla has announced that the first batch of Roche’s antibody cocktail, Casirivimab and Imdevimab, is now available for treating Covid-19 in India, with a second batch of the drug to be available next month.

    Casirivimab and Imdevimab are human immunoglobulin G-1 (IgG1) monoclonal antibodies that act against SARS-CoV-2 spike protein to hinder the attachment of the virus and its human cell entry."
    https://www.pharmaceutical-technology.com/news/cipla-roche-antibody-cocktail/

    They also claim it was also tried on Mr Trump. However, its efficacy will be known later. But I have this question:-

    When a person is infected from Covid-19 virus or given whoke virus based vaccine (live attuned or inactivated virus) whether he is also exposed and protected from cocktail of antibodies i.e. nucleocapsid, spike etc.? Whereas when he is exposed to víral vector or mRNA type single unit based vaccines, he will simply get one antibody to spike protein? If so, what can be the outcome from these two types?

    Best wishee.
     
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  3. RainbowSingularity Valued Senior Member

    Messages:
    6,670
    ...
    there is no question in your sentence but you have put a question mark on it

    this is a question
    the answer should be easy to find in google
    did you google it(search on the internet?) ?

    between what ?
    you have missed an entire question to premise

    i suggest you go back and check and then post your other premise question.
    or edit and re post your question

    thats a very big reply to such a broad question
    you may wish to add some specifics

    also
    is the patient in serious covid condition in ICU ?
    what point is the medication being given ?
    severe covid ?
    mild covid
    a-symptomatic covid etc

    refine your question & terms if you wish better quality answers

    also
    is this given to people before they get covid ?
    are they tested first and then given it when they have a negative test ?
    are the patients complex ? do they have other conditions ?
    diabetic
    heart disease(blood pressure issue and bleeding hemophilia etc)
    obesity
    etc etc
     
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  5. KUMAR5 Registered Senior Member

    Messages:
    923
    Sorry, you could not understand. This was question.
    whether he is also exposed and protected from cocktail of antibodies i.e. nucleocapsid, spike etc.?
    Moreover, it is for general purpose not for specific purpose. Other details are given in link provided by me.
     
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  7. RainbowSingularity Valued Senior Member

    Messages:
    6,670
    ok
    thanks
    i have no desire to help make other people rich who will not pay me to do so

    they can do their own marketing and pay for it themselves
     
  8. KUMAR5 Registered Senior Member

    Messages:
    923
    Ok then you are free to avoid. Simply avoid excess teaching, pulling skin from hairs and idiotically speculating. Bye and Thanks.
     
  9. KUMAR5 Registered Senior Member

    Messages:
    923
    I just want to clear my OP:

    Do we get some cocktail of antibodies or say many type of antibodies, when we are infected by Covid 19 virus or take whole virus based vaccine? If yes, is it more effective to control infection than single antibody by mRNA or viral vector based vaccine?
     
  10. KUMAR5 Registered Senior Member

    Messages:
    923
    ". Similar to other coronaviruses, SARS-CoV contains four structural proteins, including spike (S), nucleocapsid (N), membrane (M) and envelope (E) proteins. All these proteins may induce humoral and cellular immune responses during viral infection. Characterization on the antigenicity and immunogenicity of SARS-CoV is important for developing effective diagnostics, therapeutics and vaccines."

    It is about SARS-Cov. But it may also be applicable in case of SAR-Cov-2 virus. Does it suggest a cocktail of antibodies and cellular immune response happen in case of natural virus infection. By vaccination??
     
  11. KUMAR5 Registered Senior Member

    Messages:
    923
    "Similar to other coronaviruses, SARS-CoV contains four structural proteins, including spike (S), nucleocapsid (N), membrane (M) and envelope (E) proteins."

    As I quoted above in my last post, it is to be well understood, whether covid specific antibodies generated due to above 4 proteins/antigens are same in quality but just differ in quantity? I tried to understabd it by writing to many labs but they are not replying on it. In sense, will their be a Cocktail of generated antibodies due to immune response against a whole virus or single but simply differ in quantity?
     

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