I'm trying to look into whether the medical profession is truly scientific and what "based on science" means exactly. I want to know how I can be sure that most studies in medicine are unbiased. I know that Dr. John Ioannidis wrote a famous paper on how most published research findings are false. And I read a summary of an article in the NEJM about how the studies on antidepressants only get published if they seem to support the use of antidepressants. I also have a specific interest in pyroluria, which was dismissed by medicine in the 1970s. If people could give concise explanations of why the studies done are certainly reliable, that would be great, and then maybe we could get into more specific things.