The topic is the knowledge and subjectivity of the origin of life. Unique protein folding, is an example of well documented knowledge that is not fully addressed, since it might stimulate thinking. Instead the traditions stick to the blind use of statistics in light of this evidence making this approach subjective for many applications within life and evolution. Statistics is a powerful tool, with its many useful predictions. The wide scale utility of this powerful tool, has biased the mind to think life and evolution is based on random events. As an analogy, a screwdriver is a useful tool designed for setting and removing screws. However, if you didn't have all the correct tools for a given job, the screwdriver can also be used as a pry bar or even a small hammer. If someone gets used to all these extra extrapolated applications for the screwdriver, a real hammer or a real pry bar do not seem necessary. In the case of proteins folds, the screwdriver is not the right tool to hit the nail yet the traditions have always done it this way. If the machine is not broken don't fix it. But it is broken and needs fixing. It is important to define the limits of the statistical screwdriver since it is still useful for setting and removing screws. But we need to ween away the screwdriver hammer. To understand the how proteins can acquire and maintain unique folds, even with weak binding energy, you need to take onto consideration the impact of water. Water acts like a girdle or a nylon stocking to help shape the leg. To understand how this girdle works, you need to go back to the basics of hydrogen bonding in water. But in general terms, the oil-water analogy is useful, with the unique fold of the protein, forming a unique phase within the water relative to the folding.