Questions about Covid-19?

Discussion in 'Biology & Genetics' started by KUMAR5, Apr 26, 2021.

  1. KUMAR5 Valued Senior Member

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    Yes vaccines sre not antibodies but these are reason to stimulate their secretions by lymphocytes. Now when it is clear vaccines or natural infection promote immunological memory then how antibodies to Covid are consistently detected? Does it not suggest some trigger remain always present which keep on stimulatingvmemory cells to secrete antibodies? What it can be?
     
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  3. RainbowSingularity Valued Senior Member

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  5. KUMAR5 Valued Senior Member

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    Yes, this is Immunological memory. But my confusion is that how antibodies to covid are consistently detected for long time post infection cure or post vaccination? As you told (for a while at least) antibodies should only be detected when memory cells are activated by reinfection for short time. Their consistent oresence in body do raise some suspición from consistent ongoing immune response by some consistent trigger. Can this virus have two states? Acute and chronic/latent due to this logic or some active traces of virus still left in bodyvpost infection cure or post vaccination for long term?
     
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  7. RainbowSingularity Valued Senior Member

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    fyi if your looking for research grant money

    https://en.wikipedia.org/wiki/List_of_countries_by_number_of_billionaires

    https://en.wikipedia.org/wiki/List_of_Indian_people_by_net_worth

    The list of richest Indians by net worth based on an annual assessment of wealth and assets compiled and published by Forbes magazine. As of 2020, India has 102 billionaires which put the country fourth in the world, after the United States, China and Germany. The number of Indian billionaires have reduced to 102 from 106 in 2019.[1] Mukesh Ambani has been the richest Indian for 13 consecutive years.[2] He is currently world's sixth-richest person.[3] Savitri Jindal is currently India's richest woman topping the list at 19th position.

    no shortage of lots and lots of very very rich indians in india

    india is a fascinating country
    mixed half n half with on one side
    very old superstitious conservative heavily religious people
    and on the other the modern urban generation who are (the better ones) very switched on clever & worldly)
    a majority proportion of indian core society is still governed by that old world superstitious religious conservatism
    most modern indians i have met & talked with privately need to live a dual life reality between that old world social compliance superstitious compliance & modern new world needs.

    generally indians are about the same racism level as white american upper middle class

    what has that got to do with science of Covid
    because depending on how you project and publicize science or miss information about science
    you inevitably will be causing the deaths of thousands & or causing suffering of thousands.

    meanwhile the Indian society is locked into a difficult struggle to advance its own culture
    only indians can solve this uniquely indian problem
     
    Last edited: Apr 28, 2021
  8. RainbowSingularity Valued Senior Member

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    7,217
    https://en.wikipedia.org/wiki/Immunological_memory

    you need something to read ?

    https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/immunologic-memory

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    Last edited: Apr 28, 2021
  9. RainbowSingularity Valued Senior Member

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    keep in mind at least 50% of all indians will not want the covid vaccine
    they do not believe in vaccines
     
  10. KUMAR5 Valued Senior Member

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  11. KUMAR5 Valued Senior Member

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    No nothing like it. I simply want to satisfy myself.

    Yes, regional and environmental disparities matter. We do use our inharent mind alongwith our acquired mind.

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  12. RainbowSingularity Valued Senior Member

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    i see you making no effort to meet me half way with your own comments about understanding
    it looks like you are surfing responses to create something
    something that could easily be anti-vaxer media if interpreted in the wrong way or miss used

    you appear to be asking everyone else to do all the work for you

    just like cult leaders do to control peoples thinking & avoid ever having to show they did not know something or can be wrong about things

    so now ... for me
    you are in that box
    which has a "do not disturb" sign on it

    ...
     
  13. KUMAR5 Valued Senior Member

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    No, you misunderstood quickly. I am a vaccinated person. How then I can go against these? Yes, it is everyone's fundamental right to better understand about food which he is taking. Moreover many things are still unclear in science esp in Covid. So we have full justification to better understand everything in science. I shall be final when it will be final. Untill then, I shall go on digging for better understanding. Now just tell me about my 2nd question:
    Should we disturb/change/modify virus natural genome n its activity by various interventions and practices ? May it be in its dead state or in live state?
     
  14. billvon Valued Senior Member

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    20,657
    Because during specific immune response (either to a pathogen or a vaccine) antibodies are produced. They last a few months, then denature. A specific sort of cell - B memory cells - retains the genetic code required to make the antibody. They can remain dormant for years, even for decades. But when that antigen is seen again - boom! They start producing tons of antibodies very quickly.

    https://en.wikipedia.org/wiki/Memory_B_cell

    All viruses are latent. Without the right kind of host cell a virus does nothing. Thus if a virus accumulates within (say) scar tissue that isn't well perfused, it can hang around for a while and basically be ignored by the immune system. Since 99.99% of the time this is just a remnant of a larger infection, the body already knows how to fight it. Very rarely it can cause a secondary infection that manifests as something else (like shingles.)
     
  15. KUMAR5 Valued Senior Member

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    1,221
    I also read above link previously. Look at this part from that link:.
    "Memory B cells circulate in the blood stream in a quiescent state, sometimes for decades.[1] Their function is to memorize the characteristics of the antigen that activated their parent B cell during initial infection such that if the memory B cell later encounters the same antigen, it triggers an accelerated and robust secondary immune response.[2"
    From this link and from your post, it is indicative that:
    1.long term antibody in substancial quantity is a function of B cells on finding the trigger. My concern is, how these persist in body for long say 6 months+ in case of covid?
    2. Some remainants of larger infection persist in body which body try to clear them. This justify my concern sbouut possibility of consistent and long term immune response resulting long term antibodies. Hence now we can suspect possibílitu of chronic/ latent or long term phase of covid which either may cure fully or got worse (horrible).
     
  16. KUMAR5 Valued Senior Member

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  17. billvon Valued Senior Member

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    Those memory B cells persist for decades.
    First off, you don't need to imagine some mechanism whereby infections persist in the body. SARS-CoV-2 is prevalent in our society, and once we stop masking/distancing etc people will be exposed to it. That alone will trigger antibody production. Indeed, those antibodies, acting on a small infection, are why you have immunity.

    Second, antibodies don't last long. Re-read the above note.
    Why not learn the science instead of making things up to "suspect?"
     
  18. Write4U Valued Senior Member

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    18,613
    There seems to be some problems with people who take immunosuppressants for organ transplants, etc.

    Apparently the suppressants also suppress the vaccine effectiveness.

    Taking Immunosuppressants? Fauci Says Get the COVID-19 Vaccine
     
  19. KUMAR5 Valued Senior Member

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    1,221
    Yes, memory B cells persist not the antibofies unless there is ongoing immune or healing reponse is continuing. Just a kinetic and potential difference.

    Yes this is also possible if wé anticipate we are daily getting infection. I can not imagine it becsuse if it would have been happening, everybody dhould dhow positive antibody test. But it is not yet observed.

    On the contrary I am making this an issue, how antibody are tested positive post virus exposure for orolonged time in case of Covid?

    Suspecting and thinking, why apple fallen on head or ground, do add. Please read first line of my OP. Many many things are still pending to know in science.
     
  20. KUMAR5 Valued Senior Member

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    1,221
    Yes. It will mean vaccine promote kinetic immune response i.e. antibody based immune response. Immunological memory based acquisationvof potential immunity may not be interfered by infection or by vaccination. Just a logical thought.
     
  21. billvon Valued Senior Member

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    That's because people have been trying very hard NOT to get infected.
     
  22. KUMAR5 Valued Senior Member

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    Then, it will mean no persistent exposure and getting of infection is happening in whole public inspite of pademic.
    Then How antibodies persist for long post infection or post vaccination if they do not get multiple infections? Antibodies
    should fade away soon but immunological memory should persist.
     
  23. billvon Valued Senior Member

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    20,657
    Once people are vaccinated they will not be trying as hard to avoid infection. So more people will become infected at some level of infection. As long as we have enough people vaccinated, that will not result in another wave of infection - because once you are vaccinated, your odds of developing enough of an infection to become infectious are much lower.

    However, that does NOT mean that there's no infection at all - it just means that your body is much better at fighting it off now, using a plan of attack that often involves antibodies.

    So you get vaccinated. You have antibodies for months to years. You have the ABILITY to produce those antibodies for years to decades. (Probably; no one has data going for more than 16 months so far for SARS-CoV-2, but that's the usual progression.) At first you get moderate amounts of reinfection since newly vaccinated people will be out and about in a population that still has significant infection rates. Those will produce more antibodies. As time goes on and the disease dies back, that will happen less and less often. But as it is likely to remain endemic in the world for a few years, we will still see people with antibody responses to infection challenges.
    Once again - memory B cells.
     

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