Study? Hell, I've published on those topics. Although I'm not a biochemist, and am not sure what "selfish gene-oriented" is supposed to mean. Also I wouldn't put Markov chains in the class of biologically-inspired computation. Neural nets and evolutionary programs would be the other big ones (to the extent the difference between a genetic algorithm and an evolutionary program is anything more than the difference between a degree in CS and one in EE, that is). "Metaphor?" Evolutionary programs are actual instances of these mechanisms. The selfish gene interpretation is just as applicable here as in biological evolution (well, with the modification that it's now a selfish "machine parameter" or somesuch).