Tell me, It is wrong on Infection?

Discussion in 'Biology & Genetics' started by KUMAR5, Apr 28, 2020.

  1. Write4U Valued Senior Member

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    It's a chemical language. Certain enzymes are chemical "commands". That's where "quorum sensing" comes from.
    https://en.wikipedia.org/wiki/Enzyme
    Without beneficial viruses and bacteria most biological organisms would die.

    Remember, the human biome is 90 % bacterial!
     
    Last edited: Apr 30, 2020
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  3. KUMAR5 Registered Senior Member

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    I need to ubderstand it deeply and technically. But grossly, it appears that it is cell/body mediated process to get virus infection not virus mediated. Ok?
     
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  5. KUMAR5 Registered Senior Member

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    Thanks. It suggests something different that probably our body only accept virus to infect esp intially.?
     
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  7. Jeeves Valued Senior Member

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    We don't claim that. The virus doesn't 'mediate' anything. It just happens to be present in fluid, or on surfaces where another organism can pick it up. As explained by Write4U, it can't multiply without the replicating mechanism of a more sophisticated cell.
    As to whether viruses are alive in the same sense that other organisms are considered alive, it's debatable - and endlessly debated. One theory is that they are the most primitive precursors of protozoa, another is that they're the remnant of eukaryotes that were near-fatally damaged by some environmental calamity; I've even heard speculation that they're from a planet that was broken up, rode to earth in a meteorite and barely survived the landing.
    Its own evolutionary purpose is the same as that of a jellyfish, a jack pine, a rhinoceros or a human: simply to continue existing.
    Do we, humans get any benefit from viruses? Some of them can be useful to us, but that is not their reason for being, just as we are useful to viruses as hosts for propagating their DNA, but that is not what we evolved for. All life is interconnected and interdependent; all participants in an eco-system relate to one another in some way and the survival whole is dependent on all parts functioning within certain tolerances.
    No life-form has a purpose, other than the short-term goals it sets for itself.
     
    Last edited: Apr 30, 2020
  8. KUMAR5 Registered Senior Member

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    It is quite technical. But apparently does it not suggest intracellular processes for viral movements, replication etc?
    First, I want to understand fusion and internalization of virus via ACE2. What make to affect it? Actually, if it is cell/body mediated
    we shall need to target cell/body processes instead of direct attack on Virus?
     
  9. KUMAR5 Registered Senior Member

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    Yes but it is intracellular process. I am first checking extracellular processes i.e. fusion and internalization---if cell/host mediated or virus mediated. If it is cell/host mediated, logically, we need to target cell/host system otherwise virus. Some anti-virals are also there which can target cell/host mechanisms and at basic level. Already quoted.
     
  10. KUMAR5 Registered Senior Member

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    ne against ACE2
    Then, it will instead be cell/host mediated not virus mediated. Not so? If yes, we need to instead target cells/host processes responsible for it. I read one Vaccine whicg targetted ACe2 was tried but not then pursued.
     
  11. KUMAR5 Registered Senior Member

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    The whole sense of doubting is that it is also considered as non-alive extracellular. We can not base it's mediation to infect. Hence we may instead need to target cell/host processes to check it.
     
  12. KUMAR5 Registered Senior Member

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    [A question to relax] unquote.

    If you restrict a thief not to touch your main door and not allw his entry into your home or if already entered
    throw him/them out of home and then resist his/their re-entry, can he harm you?
     
  13. Write4U Valued Senior Member

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    I think that is one of the various possible approaches. I like the idea of inhibiting quorum sensing .
     
  14. Write4U Valued Senior Member

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    He cannot harm you anyway, not until there is a quorum which triggers the virulence.
     
  15. Jeeves Valued Senior Member

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    I have no idea what you're on about.
     
  16. Write4U Valued Senior Member

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    That's what we do with cancerous cells, no? Not very gentle on the host.

    If you mean there is no "intent' you're right. Intent is not required. Its a chemical process. The communication is via chemistry. All we need to do is to confound the language and the virus remains benign.

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    Abiogenesis does not require motive or intent. It's a mathematical electro-chemical function . The virus is a transitional organism. Actually, it is thought that the virus devolved from a common ancestor with the bacteria, which was able to copy itself.
     
  17. KUMAR5 Registered Senior Member

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    When it can replicate or form its own quorum, how can we say, it can not harm?
     
  18. KUMAR5 Registered Senior Member

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    Do virus infect a dead person?
     
  19. KUMAR5 Registered Senior Member

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    Yes, it receptor mediated fusion( also internalization). Then, should we first not target these two...fusion and internalization at basic level? Some drugs are already there in application...need to be carefully studied specifically and re-purposed. Already quoted.
     
  20. Write4U Valued Senior Member

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    Maybe for a couple of hours as the cells begin to die. When decay sets in, that is from a different competing virus or bacteria. btw. Some viruses use bacteria to procreate.

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    How long HIV virus survive in a Dead Human body
    www.thebody.com/article/long-hiv-virus-survive...

     
    Last edited: Apr 30, 2020
  21. Write4U Valued Senior Member

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    Not until a quorum is reached. That's the beauty. We can prevent the bacteria or viruses from reaching a quorumb by chemical language. We need to learn the language !

    But the cure; no virulence, no procreation and the virus dies by natural selection without acquiring immunity.
     
  22. Write4U Valued Senior Member

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    This may be of interest;

     
  23. Write4U Valued Senior Member

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    And for good measure;

     

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