Diabetes & genetics Questions?

K

Kumar

Registered Senior Member
Hello,

I am searching awnsers of following important questions:-

1. Whether variations in mucus quantity & quality esp. in intestines resulting in variations in absorption can be an predisposed or acquired immune defence response mediator & physiological?

2. Whether quantity & consistency of intestinal mucus or mucus on intestinal lining has been studied & if related to increased or decreased sugar absorption resulting variations in blood glucose levels? Mucus along with pH is immune defence related mediator & barrier so its instabilities or imbalances may be related to presiposed instabilities.

3. Whether insulin's receptors on target cells can be down-regulated due to excess or increased insulin's exposure to target cells? Down regulation of receptors do happens in case of other harmones.

Best wishes.
 
Right. Have you tried Nutrition references, or looked at anything?
that is, what do you know about the intestinal lining, or the human body in general?
 
I tried at medlineplus, internet search etc. for "mucus in intestines". But it does not cover mucus relating to absorption but just mucus in stool.

For down regulation, I studied following link;

Receptor downregulation

[edit] Mechanism
For insulin, the process of downregulation occurs when there are elevated levels of the hormone in the blood. When insulin binds to its receptors on the surface of a cell, endocytosis of the hormone receptor complex is initiated, only to be subsequently attacked by intracellular lysosomal enzymes. The internalization is multi-purposed, as it provides the pathway for degradation of the hormone and also a way to regulate the number of sites that are available for binding on the cell’s surface. At high plasma concentrations, the number of surface receptors for insulin is gradually reduced by the accelerated rate of receptor internalization and degradation brought about by increased hormonal binding.
http://en.wikipedia.org/wiki/Downregulation
Click to expand...

Though above link clear this aspect, but it is bit suprising and may or may not be valid in view of "medicating insulin's exposure on diabetes2".

Pls tell something.
Click to expand...
 
Mate, I'm not a doctor; are you a diabetic?

If you think you're having (or someone else is) some kind of reaction, or you're concerned about what the insulin is doing, the only advice I can offer is to go and see one. A GP might be a start, and ask them about seeing a specialist.

Or if you're just interested, well, keep reading those research papers. There are lots of regulated pathways (and most regulatory ones are also regulated), gene expression is very complex with lots of interacting processes, you wonder how a cell manages it (but obviously cells manage "it" quite successfully).
 
One manufacturer of a cough syrup (composed of ambroxol, terbutaline, guaiphenesin & menthol) claimed that their syrup 1. enhances antibiotic penetration and is mucolytic & mucokinetic 2. Improve airway clearance & added antiallergic action, 3. US FDA approved expectorant 4. Local soothing & counter irritant action respectively to its composition mentioned above.

If intestinal mucus quality and quantity can be related to motality, digestion and absorption of foods, the claim can be relevant. Such proteolytic, mucolytic, Mucokinetic & muco-expectorant can also be linked to digestive enzymes(pepsin, trypsin etc.) whose secretions can be effected by digestive evironment/pH. Digestive microorganisms/GUT flora or Probiotics can also be related to breakdown of protiens, mucus etc. I am bit surprised, whether this issue is less attended inspite of having prime importance and acid, base & water(mucus) balance can also be related to constitutional and immune mediators.










































with claimed that their syrup "en
 
One more relevant aspect can also be there about insulin resistance:

Insulin's exposure to target cells in diabetic type2 can be continual
& increased either due to natural reasons by irregular eating habit,
modern & sed. lifestyle & stress OR as a result of medication programme.
As such. natural or medicated instabilties in natural Insulin oscillations can also be thought to be be related to insulin resistance as per following quote:-


"Insulin oscillations


Insulin release from pancreas is pulsatile with a period of 3-6
minutes. [1]The insulin concentration in blood increases after meals
and gradually returns to basal levels during 1-2 hours. However, the
basal insulin level is not stable. It oscillates with a regular period
of 3-6 min. After a meal the amplitude of these oscillations increases
but the periodicity remains constant. [1] The oscillations are
believed to be important for insulin sensitivity by preventing
downregulation of insulin receptors in target cells. [1] Such down
regulation underlies insulin resistance, which is common in type 2
diabetes. It would therefore be advantageous to administer insulin to
diabetic patients in a manner mimicking the natural oscillations. [..
Disturbances of the insulin oscillations occur early in diabetes and
may contribute to insulin resistance.
http://en.wikipedia.org/wiki/Insulin_release_oscillations "


Under such consideration, how this aspect alongwith increased
insulin's exposure resulting downregulation of insulin's receptors,
which can be common in type2 diabetics, address insulin resistance?
 
In all, following links can be studied & checked to know more about IR;

Insulin
http://en.wikipedia.org/wiki/Insulin


Insulin degradation
http://edrv.endojournals.org/cgi/content/full/19/5/608#F1


Insulin Oscillations
http://en.wikipedia.org/wiki/Insulin_release_oscillations


Downregulation
http://en.wikipedia.org/wiki/Downregulation


These suggest to me that abnormalities in insulin's exposure, normal
degradation & oscillation can cause increased exposure to target cells resulting downregulation & decreased senstivity.
 
Does it not look quite possible/logical that one can get habit or insenstiveness or physiological tolerances or dependances or addictions or resistances etc. chronic exposures of any odd thing or and/or in odd quantity?
 
Excercising muscles may need less/no insulin for glucose uptake. Diabetics2 do get initiation of somewhat lazyness or sed. lifestyle. Can such initiation be meant for a purpose to utilize more insulin and avoid downregulation.
 
Kumar said:
Hello,

I am searching awnsers of following important questions:-

1. Whether variations in mucus quantity & quality esp. in intestines resulting in variations in absorption can be an predisposed or acquired immune defence response mediator & physiological?

2. Whether quantity & consistency of intestinal mucus or mucus on intestinal lining has been studied & if related to increased or decreased sugar absorption resulting variations in blood glucose levels? Mucus along with pH is immune defence related mediator & barrier so its instabilities or imbalances may be related to presiposed instabilities.

3. Whether insulin's receptors on target cells can be down-regulated due to excess or increased insulin's exposure to target cells? Down regulation of receptors do happens in case of other harmones.

Best wishes.
Click to expand...
I would like to know that too. My wife is very sick with a severe mutated form of diabetes mellitius... She makes way too much insulin... :(
 
Though, I thought too much in this topic, probably you or others may find/seek the truth.
 
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