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pH changes & Mutations
- Thread starter Kumar
- Start date
Firslty, the answer is no, because the necessary change in pH will first kill you.
Secondly, there is no need to change pH in your body if you would like to have these changes inherited in future generations. You would only need genetic mutations in your reproducing cells.
Secondly, there is no need to change pH in your body if you would like to have these changes inherited in future generations. You would only need genetic mutations in your reproducing cells.
Doesn't our body have differant pH at differant sites? Differant enzymens, hormones etc. works differantly on differant optimal pH & temp.. Moreover, we may get some effects as under:-
Most people who suffer from unbalanced pH are acidic. This condition forces the body to borrow minerals—including calcium, sodium, potassium and magnesium—from vital organs and bones to buffer (neutralize) the acid and safely remove it from the body. Because of this strain, the body can suffer severe and prolonged damage due to high acidity—a condition that may go undetected for years.
Kumar said:Doesn't our body have differant pH at differant sites? Differant enzymens, hormones etc. works differantly on differant optimal pH & temp.. Moreover, we may get some effects as under:-
I think there are more differences in pH on an intracellular level. But mostly I think it is the same. Extreme pHs will probably be resticted to cell organelles such as the vesicles inside the cell such as lysosomes
pH for Optimum Activity Enzyme pH Optimum
Lipase (pancreas) 8.0
Lipase (stomach) 4.0 - 5.0
Lipase (castor oil) 4.7
Pepsin 1.5 - 1.6
Trypsin 7.8 - 8.7
Urease 7.0
Invertase 4.5
Maltase 6.1 - 6.8
Amylase (pancreas) 6.7 - 7.0
Amylase (malt) 4.6 - 5.2
Catalase 7.0
The above is the list of some enzymes with optimal pH. Most are related to digestive tract. I think you are right to indicate that "there are more differences in pH on an intracellular level". We need to understand it for its effect on causing mutation.
Kumar said:The above is the list of some enzymes with optimal pH. Most are related to digestive tract. I think you are right to indicate that "there are more differences in pH on an intracellular level". We need to understand it for its effect on causing mutation.
There is no point in looking at mutations in ordinary cells. They will not be transmitted to the next generation.
Kumar said:How then hereditory diseases are trasmitted from one generation to next generation? How each & every cell is capable of producing similar clones? There has to be some cordinated activity for the same.
The mutation is present in the sperm or egg cell.
Kumar said:Just assume that only few cells got mutations, how then these mutations will be transfered in the sperm or egg cell?
Btw, whether all clones made from differant cells of same person will be exactly similar or not?
You can't transfer any mutations from the somatic cell lines to the germ line.
Kumar said:How then heriditary diseases are transfered to next generation?
Btw, whether all clones made from differant cells of same person will be exactly similar or not?
Beause the disease is already present in the germ line.
You can't acquire a hereditary disease by mutations in your somatic cell lines.
It is a direct mutation in the germ line. Germ line and somatic line never mix.
Kumar said:Do all the diseases of hereditary nature causes mutations in germ line?
Let me reformulate it for you.
All diseases of hereditary nature are caused by mutations that are perpetuated in the germ line.
Pls also reply: whether all clones made from differant cells of same person will be exactly similar or not?[/QUOTE]
They will not be the same, because DNA is modified differently in different cells. That is why it is easier to clone with certain cell types than with others.
Simple Cuboidal Epithelium constitute the germinal epithelium which produces the egg cells in the female ovary and the sperm cells in the male testes, only. What is the relation of whole body with these germ line in aquiring the any hereditary disease's mutation?
How can we say clones are duplicate of any person without mind?They will not be the same, because DNA is modified differently in different cells. That is why it is easier to clone with certain cell types than with others.
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Kumar said:Simple Cuboidal Epithelium constitute the germinal epithelium which produces the egg cells in the female ovary and the sperm cells in the male testes, only. What is the relation of whole body with these germ line in aquiring the any hereditary disease's mutation?
No relationship in this respect.
Kumar said:How can we say clones are duplicate of any person without mind?
I'm not saying it.
Now, how does germ line aquire mutation of disease with in one's life time & how body's pH is related to environment of testes, ovary or of germinal epithelium?spuriousmonkey said:No relationship in this respect.
I'm not saying it.
How much then differant clones of same person can be differanciated with each other & with the person? Can clones aquire hereditary diseases?
Kumar said:Now, how does germ line aquire mutation of disease with in one's life time
By having an unfortunate mutation event. And usually the mutation is not dominant but recessive, so it needs to meet another recessive allele before the phenoype of the disease shows.