The Pharmacology Sticky

Being a person who has not and does not use drugs, and is firmly against it for myself, besides alcohol . . . .
What a quaint thing to say! Alcohol is a drug, dude! And by many measures it's one of the worst. While intoxicated: impaired judgment, loss of alertness, drop in IQ, slower reaction time, all the while feeling just the opposite of all these. Coming down: Bad withdrawal symptoms, drowsiness, irritability. Long term: addictive, long recovery from addiction, liver damage, weight gain.

Compared to alcohol, marijuana is milk and cookies, especially if you don't smoke it, which nobody in their right mind does any more.
 
I no longer use illegal drugs, since 1994 when I became a Christian, and I very rarely drink, but I can sum what I do know into a few parameters:

My favorite drug was LSD. Yes, I've had a few scary moments; but, I love art, and the living, flowing art and the grand awes created with LSD were wonderful to me.

My next favorite was weed, but it's hard to say why, for the thought of weed sort of bores me now -- much like alcohol bores me now.

My next favorite was any kind of speed.

My least favorites were the downers, including heroin, but I nonetheless consumed quite a bit of "T," which is actually PCP. Looking back, I think it was the 'high' per dollar ratio, not the high itself, that attracted me to the drug -- as well as a girlfriend who loved it.

Cocaine is strange for me because it has no effect on me when I'm straight, but it will clear my head up to safe-driving sobriety if I'm utterly wasted on PCP.

Only one drug scares me -- crack. I've never used it, but I saw one guy who had a top-secret security clearance and who ended up in prison and who lost everything he had from the addiction. Normal good character is not a defense to the drug, and I've heard the story many times.

I have challenged character at best -- and so I definately do not want to try crack.

Very Respectfully,
Ray Donald Pratt
 
What a quaint thing to say! Alcohol is a drug, dude! And by many measures it's one of the worst. While intoxicated: impaired judgment, loss of alertness, drop in IQ, slower reaction time, all the while feeling just the opposite of all these. Coming down: Bad withdrawal symptoms, drowsiness, irritability. Long term: addictive, long recovery from addiction, liver damage, weight gain.

Compared to alcohol, marijuana is milk and cookies, especially if you don't smoke it, which nobody in their right mind does any more.

I did say "besides alcohol" which I thought made clear that I know it is a drug.
And just because I drink occasionally does not mean in any way that I abuse it.
 
As far as i know, alcohol can has some significant benefits. Essential to life? Not really but it is a blood thinner.
 
Also what I've heard, John99.

What a horrible life to lead, being addicted to it though.
Or addicted to any drug, for that matter.
 
SSRI medication for fatigue.

I have been taking Citalopram for a number of reason and it initially had a very positive effect on my energy levels. I have been chronically fatigued for many many years and this was the first treatment that has ever given me a long terms benefit (a few months).

However, the effect has now greatly worn off. So with this in mind I am having a changed of medication; to Venlafaxine.

With this in mind a have a few questions.

1. Has anyone had any medication that assists with a fatigue problem? If so what?

2. If I stop taking Citalopram for a number of months am I likely to be able get energy benefits from it once I start taking it again?

Cheers :)
 
I've just looked up citalopram on wiki, and it says this:

Citalopram is a Pgp substrate and is actively transported by that protein from the brain. The efficacy of citalopram in people possessing a certain version of Pgp (genetic TT-allele) is likely to be diminished. This suggests that in non-responders to citalopram a switch to an antidepressant which is not a Pgp substrate, such as fluoxetine (Prozac, Fontex) or mirtazapine (Remeron)—but not to venlafaxine (Effexor), amitriptyline (Elavil) or paroxetine (Paxil), which are Pgp substrates—may be beneficial.[3]
 
Thanks for looking that up, interesting.

It weird I seem to be having an energy boast from cutting down on the current meds. I guess this is all trail and error :)
 
I just heard a report today about a woman treated with antidepresants for three years for fatigue without success. Ultimately, she found out the actual problem was low thyroid levels.
 
Get a sleeping pill - go to bed at 10 pm, wake up at 6 am, stop wasting your time all night.

If that doesn't work, stop seeing a psychiatrist and go to a real doctor to get diagnosed with diabetes type II.
 
I have a family member who was on a number of antidepressants which did nothing for them prior to getting on Venlafaxine which seemed to help with the depression and the ability to concentrate. I think energy levels improved but that was a lesser effect.

Eventually the Venlafaxine stopped working. Then they were put on Citalopram which worked for a while and then stopped working. My feeling is that both Citalopram and Venlafaxine work for about five months and then you have to start upping the dosages to get them to continue working. At some point upping the dosages becomes less effective and there may be liver toxicity issues. Switching back and forth between those two drugs every six months might be better than staying on one of them.

I am not thinking in terms of energy levels because that was not the primary issue for my family member. Doctors rely on the info from the pharmacological industry and I think the industry downplays the fact that drugs lose their effectiveness.
 
Get a sleeping pill - go to bed at 10 pm, wake up at 6 am, stop wasting your time all night.

If that doesn't work, stop seeing a psychiatrist and go to a real doctor to get diagnosed with diabetes type II.

Diabetes type II?

Are you sure?

He doesn't mention diabetes like symptoms..
 
Diabetes type II?

Are you sure?

He doesn't mention diabetes like symptoms..

Diabetes isn't a "Yes" or "No" type of deal. A lot of people have Type II diabetes that goes in and out of remission throughout their lives dependent on their activity and diet and never know it. A huge symptom of a very light diabetes is the inability to wake up - and chronic fatigue. Numbness of the extremities usually only comes after it's full blown.
 
With this in mind a have a few questions.


Great, but put them to medical professionals. :) Don’t ask them on an internet science forum because you invariably get ill-advised ill-informed (sometimes outright dangerous) advice like this from people who have zero education in the medical field and who want to push agendas....

Get a sleeping pill - go to bed at 10 pm, wake up at 6 am, stop wasting your time all night. If that doesn't work, stop seeing a psychiatrist and go to a real doctor to get diagnosed with diabetes type II.
 
Great, but put them to medical professionals. :) Don’t ask them on an internet science forum because you invariably get ill-advised ill-informed (sometimes outright dangerous) advice like this from people who have zero education in the medical field and who want to push agendas....

What exactly is my agenda? Is it my belief that most exhaustion is the result of inconsistent schedules and poor discipline? I thought that was fact.
 
DMT: more than meets the eye to psychadelics?

Been doing a bit of reading on DMT (dimethyltryptamine) and am rather curious if there is more behind psychadelic drugs specificly DMT than what is popularly described to the general public IE: "just say no to drugs" lol??

It seems a fair amount of research had gone into attempting to understand psychadelics and their effect on people specificly LSD and more recently DMT.

Some of the accounts of test subjests and users of DMT are pretty interesting and similar in some areas.

The book iv'e been reading is "DMT The Spirit Molecule"

At work so i'll have to make this short till im off but:

Anyone here experienced effects of DMT?

Anyone have any insight on it?

Thanks
Sly
 
DMT occurs naturally in many species of plants often in conjunction with its close chemical relatives 5-MeO-DMT and bufotenin (5-OH-DMT). DMT-containing plants are commonly used in several South American shamanic practices. It is usually one of the main active constituents of the drink ayahuasca, however ayahuasca is sometimes brewed without plants that produce DMT.

It occurs as the primary active alkaloid in several plants including Mimosa hostilis, Diplopterys cabrerana, and Psychotria viridis. DMT is found as a minor alkaloid in snuff made from Virola bark resin in which 5-MeO-DMT is the main active alkaloid.[18] DMT is also found as a minor alkaloid in the beans of Anadenanthera peregrina and Anadenanthera colubrina used to make Yopo and Vilca snuff in which bufotenin is the main active alkaloid. Psilocybin, the active chemical in psilocybin mushrooms can also be considered a close chemical relative for the psilocybin molecule contains a DMT molecule at the end as with other close chemical relatives (4-Phosphoryloxy-N,N-dimethyl-tryptamine).

The psychotropic effects of DMT were first studied scientifically by the Hungarian chemist and psychologist Dr. Stephen Szára, who performed research with volunteers in the mid-1950s. Szára, who later worked for the US National Institutes of Health, had turned his attention to DMT after his order for LSD from the Swiss company Sandoz Laboratories was rejected on the grounds that the powerful psychotropic could be dangerous in the hands of a communist country.


DMT during various stages of purification in an illegal drug laboratory in Los AngelesDMT is generally not active orally unless it is combined with an monoamine oxidase inhibitor (MAOI) such as a reversible inhibitor of monoamine oxidase A (RIMA), e.g., harmaline. Without a MAOI, the body quickly metabolizes orally administered DMT, and it therefore has no hallucinogenic effect unless the dose exceeds monoamine oxidase's metabolic capacity (very rare).

Other means of ingestion such as smoking or injecting the drug can produce powerful hallucinations and entheogenic activity for a short time (usually less than half an hour), as the DMT reaches the brain before it can be metabolised by the body's natural monoamine oxidase. Taking a MAOI prior to smoking or injecting DMT will greatly prolong and potentiate the effects of DMT. If DMT is smoked, injected, or orally ingested with a MAOI, it can produce powerful entheogenic experiences including intense visuals, euphoria, even true hallucinations (perceived extensions of reality).

http://en.wikipedia.org/wiki/Dimethyltryptamine
 
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