Can you equally tell me how external stimuli produce changes in the brain that can account for choices that, due to neural plasticity, produce further, self-directed changes in the brain? Can you predict what stimuli will spur what endogenous changes, or even exogenous changes? Until you can, the reductionist view may be lacking in explanatory power. We can only "cut the soul out" if the reductionist view offers equal explanatory power. Now I assume you think it does, but without evidence that is as much "science-of-the-gaps" as belief in a soul may be "dualism-of-the-gaps". The difference is that the reductionist view implies there may be evidence to support it, while the dualist view does not. The stronger claim requires stronger evidence. Dualism does not make evidentiary claims. Any thoughts on the causal connection to reference argument for knowledge that we are not brains in vats? Or just sticking to what you feel are easy arguments?