The real denial is denying the significant active role water played/plays in shaping the direction of evolution. If we include water, much of the randomness goes away and life assumes a sense of direction based on a version of natural selection, which best takes advantage of the inherent properties of water.
The high and low density water domaines are connected to the dual nature of hydrogen bonding. Polar hydrogen bonding between H+ and O- benefit by closing distance and tend to make the water denser. While covalent hydrogen bonding between hydrogen and oxygen need to overlap covalent bonding orbitals, which is optimized if the atoms spread out, forming less dense water domaines. The energy different is small and the water can flip back and forth without ever breaking the hydrogen bond; changes color.
In liquid water, this effect occurs within water clusters composed of 280 water molecules which can pucker or expand. Besides the physical volume changes within the aqueous continuum, since the covalent bonding requires overlap of wave functions, this version lowers the water entropy compared to the polar hydrogen bonding which has more freedom of position for polar attraction.
The changes within water shape, from high and low density, not only push and pull but can increase and decrease the local free energy. This additional binary feature of water is a prelude to the entropic force, since physical pressure changes created by osmosis (osmotic pressure) can be used to tweak the volume of the expanded/contracted domains, adjusting the local entropy and free energy.
With reverse osmosis, we apply pressure to purify water back to lower entropy; away from ionic association. This means anything in the water will see this lowered water entropy and will need to adjust its own entropy to be more in line. The water represents about 9 out of every 10 molecules in the cell, and carries the weight to enforce the osmotic pressure/volume/free energy.
As a basic application, as cells prepare for cell cycles, the membrane unsaturated. The unsaturation makes the membrane more fluid. This loosening of the membrane makes it easier for sodium cations to diffuse back into cell. The net result is the entropic force is less enforced by the cell; less ionic gradient to drive osmotic pressure. This simple global change in the water, would be expected to increase cellular entropy since water entropy goes up. This is reflected by rapid synthesis followed by the disruption of many cell structures such as the eventual loss of the nuclear membrane and Golgi apparatus caused by the entropy boost in the water.