The Pharmacology Sticky

Neildo said:
"Pure" DMT shits all over Salvia, but they're also completely different. Preference, really.

- N
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in this order...

Salvinorin-A
DMT
LSD

I agree, DMT probably wins but pure salvinorin-A is arguably at least just as strong. More tests (controlled or otherwise) have been done with pure DMT/5-Meo-DMT:. it is easier to come to such a conclusion. DMT will easily propel people beyond mid/high dose(lower end) (I say this because a 'fingerprint' will leave you forever changed) LSD experiences, in a completely debilitating instantaneous way (smoked).

Also, there are many "research chemicals" out there with nearly equal strengths; especially psychedelics that require 1-2milligram sized dosages (LSD required 1/10th of a milligram or 100ug).

Again, it is very hard to compare all chemically altering substances as they all function differently (generally) and there are so many factors involved here. While a 100ug dose of LSD can be equated to a similar psilocybin experience, but up that to 350ug and it's a whole other story.

I apologize for the rant, hope it makes sense and i didn't just bump a 3 year old thread.

ABOVE ALL, BE SAFE!!! DO YOUR RESEARCH (and check your sources)!!! TRIPLE CHECK YOUR WEIGHTS AT DOSAGES THIS LOW.

That is all...

-Spaz-
 
Vkothii said:
Did you know there's a synthetic ester of THC that's 200 times stronger than ordinary THC?
It's a stereoisomer, and can't occur naturally.
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There are actually synthetic cannabinoid which are much more powerful than this. Some are as much as 800x more powerful than THC. Many of these powerful cannabinoids are also full agonists at the C1 cannabinoid receptor. The effects of a full agonist would be different and likely more profound than those produced by partial agonists such as THC.

Creeptology said:
it's certainly one of the most widespread damaging ones but it's not illegal (it should be). It's a nasty nasty drug, there is a footpath not far from where I live where industry used to dump nicotine waste (people call it the nicotine footpath). Nothing grows there, just slabs of nicotine. My biology lecturer told me about it first.
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Why should nicotine be illegal? Lack of growth at an area where nicotine is dumped is not evidence for its toxicity in humans.

hubris_personified said:
Fentanyl is the strongest opiate I've ever done. GOD i love it! I also prefer plain old m over dilaudid or h. Mainlining m is a full body orgasm but fentanyl was the same just much more intense. BTW I did that stuff for about a year & walked away from it. Now I'm back into exploring innerspace with psychedelics. I don't do E cos it screws with one's serotonergic neurons. I don't need that. But I have done IM DPT, DMT, 5-Meo-Dmt, oral mescaline, 2-CE, 2-CI, IAP, psilocybin, and of course LSD.
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You are correct, fentanyl is much more powerful dosage wise than heroin, however carfentanil is many times more powerful than fentanyl. Heroin and morphine are usually the drug of choice because they more readily cross the blood brain barrier and produce a more powerful rush and because they bind to the mu opioid receptor with more selectivity than many other opiates, resulting a greater degree in euphoria.

Also, every drug you just named screws with one of the brains many neurotransmitter systems. How do you think they produce their effects?
 
Back Pain, Marijuana, and Strange Additives

Hello!

I had a severe back injury some years ago, marijuana helps to ease that pain. When marijuana runs out you can smoke the resin. (essentially the build up of the smoke makes a tar that can be smoked again)

All these years of smoking I have only seen marijuana that turns white, even the resin turns white after smoking it. But after coughing up blood I am beginning to think some one has put strange additives in it.

The reason I know this is because for the first time in years the resin has turned a light pink instead of white, after it was depleted and smoked.

What chemical(s) turn pink or red after it has been burned?

Thanks (hopefully not opium or anything like that)

:shrug:
 
I am not sure about the chemical question, but I have another one if you don't mind.

I was wondering how much marijuana eases the pain? Did you take other medications as well? Compared to conventional medications, how well does it work?

I am curious because I have had a problem with my neck and upper back for the last yr but I am taking pain meds.
 
shorty i think weed is psychotropic, ie it acts directly on the central nervious system rather than steriodal and non-steriodial anti inflamitories which act directly on the site of the inflimation
 
shorty_37 said:
I am not sure about the chemical question, but I have another one if you don't mind.

I was wondering how much marijuana eases the pain? Did you take other medications as well? Compared to conventional medications, how well does it work?

I am curious because I have had a problem with my neck and upper back for the last yr but I am taking pain meds.
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Marijuana is surprisingly effective on some types of pain.

People with sometimes even severe pain from terminal cancers note the reduction in pain from marijuana use. And these are people who have Fentanyl arm patches and Dilaudid and the like.

Diode man, 'resin' is almost pure tar. I hope you are using a water pipe with quite a bit of water to filter that if you are smoking it. As to the pink thing, it's nothing to worry about. It's more related to the temp of the burn and etc.
 
i doubt it, weed is used reasonably widely now in pain management for people with terminal cancer. its especially useful to counter the side effects of chemo and the munchies are a benifical side effect
 
Asguard said:
i doubt it, weed is used reasonably widely now in pain management for people with terminal cancer. its especially useful to counter the side effects of chemo and the munchies are a benifical side effect
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I enjoy weed for my back pain. It isn't supposed to have garbage additives in it though. If it were legal that wouldn't happen! %$& *&% @@!$@#

John99 said:
on a scale of 1 to 10 ir is about a 2.
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The weed gets ya real stoned, its 10 for sure, but I think there is some strange chemicals on board.

EndLightEnd said:
Diodeman, are you smoking prescription shit? Ive never had resin turn pink before.
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I've never had resin turn pink before this year either!

No it isn't prescription. If it were this sort of shit would never happen!

Once I smoked half a bag and some m*ther f*ckers had put tons of pubic hairs in it to weigh it down! I didn't realize there were pubic hairs in it till it was half smoked!

The republican party is a bunch of anti-weed-pro-heroin-Nazis.


Legalize Legalize Legalize! :m: THE HERB! :m:
 
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shorty_37 said:
I am not sure about the chemical question, but I have another one if you don't mind.

I was wondering how much marijuana eases the pain? Did you take other medications as well? Compared to conventional medications, how well does it work?

I am curious because I have had a problem with my neck and upper back for the last yr but I am taking pain meds.
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One bowl of marijuana eases the pain quite nicely, and makes sleeping much easier. That is most likely 1/3rd of a gram.

But for a woman/first timer (more women are sensitive to it), I would suggest more like 1/4 of a gram. One thing for sure is that if you're using pain meds already, that may weaken marijuanas potential to help. But I'd say its worth a try on the weed, pain meds are near impossible to get off after too many years of use.

If the marijuana works for you, then I suggest getting a vaporizer, that way you don't smoke unneeded plant material.

Listen to some calm meditative music and give it a smoke.
 
You know, we're supposed to all be scientists so we should all care about preserving our brain cells and memory capabilities. Smoking weed does impact your memory from the time you smoke it until the high leaves your system, but I would like to see studies done to analyze its effects when stored in fatty tissues. Maybe its just a preconceived thought, but doesn't marijuana affect your long-term memory capabilities when used in excess for extended periods of time? I'll be a college senior after this semester so I care about my brain very much.
 
Lol, wait..wtf..how can you not notice that there are pubic hairs in it...by the time you lit some fire you should have noticed

Change the dealer.
 
Asguard said:
shorty i think weed is psychotropic, ie it acts directly on the central nervious system rather than steriodal and non-steriodial anti inflamitories which act directly on the site of the inflimation
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This is partly true. Steroids and NSAIDs do not act on the brain or CNS. Marijuana has actions on both the CNS and PNS which contribute to its analgesia.
 
jnc1110 said:
You know, we're supposed to all be scientists so we should all care about preserving our brain cells and memory capabilities. Smoking weed does impact your memory from the time you smoke it until the high leaves your system, but I would like to see studies done to analyze its effects when stored in fatty tissues. Maybe its just a preconceived thought, but doesn't marijuana affect your long-term memory capabilities when used in excess for extended periods of time? I'll be a college senior after this semester so I care about my brain very much.
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Propaganda. Marijuana does have effects on short term memory which are almost universally observed. One of the roles of cannabinoids in the brain is probably to help filter out that which is unnecessary to remember. However, effects on long term memory have not been shown in studies. Also, marijuana does not kill braincells. In fact, many of the synthetic cannabinoids have actually been shown to help prevent brain damage and promote brain cell growth. These cannabinoids are many times more powerful than any of the chemicAls in marijuana, but it's still worth looking at.
 
there is a big stink that fibromyalgia is bs.. yet there are prescription drugs available.. like lyrica ... what it does is scramble the nerve impulses... I got it after rot. cuff surgery and was given lyrica which was way too intense for me... they toned it down to something else.. but it was the same type of med... scrambled nerve impulse.

Weed does the same thing.. I can take 2 or 3 puffs and the pain is gone for 8-12 hours. Much more effective than taking Ibuprofen takes less time and certainly it's a smaller amount of stuff than the 2 pills.

It's total bs that there is so much controversy on medical use of MJ.. it's all about it cutting into the profits of the Pharma companies who own the politicians. They can't compete against something that can be grown in your backyard.

We like to say we are a free country .. yet let big business dictate what freedom is
 
The resin turns color based on the variety of weed. Pretty harmless. If you have heroin or coke or PCP in there, watch for a sharp, non-skunky smell.
 
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